Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


A kinesin mimics DNA

Primary cilia transduce cues, including Hedgehog (Hh) signals, and possess doublet microtubules that interact with kinesin motors. The kinesin KIF7 is important for Hh signalling and binds to GLI transcription factors. Haque et al. reveal that, surprisingly, GLI proteins bind a DNA-like part of KIF7 to promote their accumulation at the ciliary tip.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Role of the kinesin KIF7 in Hh signal transduction.


  1. Bangs, F. & Anderson, K. V. Cold Spring Harb. Perspect. Biol. 9, a028175 (2017).

    Article  Google Scholar 

  2. Haque, F. et al. Nat. Cell Biol. (2022).

    Article  PubMed  Google Scholar 

  3. Hui, C. C. & Angers, S. Annu. Rev. Cell Dev. Biol. 27, 513–537 (2011).

    Article  CAS  Google Scholar 

  4. Radhakrishnan, A., Goldstein, J. L., McDonald, J. G. & Brown, M. S. Cell Metab. 8, 512–521 (2008).

    Article  CAS  Google Scholar 

  5. Dong, C., Li, Z., Alvarez, R., Feng, X. H. & Goldschmidt-Clermont, P. J. Mol. Cell 5, 27–34 (2000).

    Article  CAS  Google Scholar 

  6. Ziegelbauer, J. et al. Mol. Cell 8, 339–349 (2001).

    Article  CAS  Google Scholar 

  7. He, M. et al. Nat. Cell Biol. 16, 663–672 (2014).

    Article  CAS  Google Scholar 

  8. Santos, N. & Reiter, J. F. J. Cell Sci. 127, 1500–1510 (2014).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Liem, K. F., He, M., Ocbina, P. J. R. & Anderson, K. V. Proc. Natl Acad. Sci. USA 106, 13377–13382 (2009).

    Article  CAS  Google Scholar 

  10. Tay, S. Y., Ingham, P. W. & Roy, S. Development 132, 625–634 (2005).

    Article  CAS  Google Scholar 

  11. Putoux, A. et al. Nat. Genet. 43, 601–606 (2011).

    Article  CAS  Google Scholar 

  12. Dafinger, C. et al. J. Clin. Invest. 121, 2662–2667 (2011).

    Article  CAS  Google Scholar 

  13. Bochkareva, E. et al. Proc. Natl Acad. Sci. USA 102, 15412–15417 (2005).

    Article  CAS  Google Scholar 

  14. Liu, D. et al. Cell 94, 573–583 (1998).

    Article  CAS  Google Scholar 

  15. Tukachinsky, H., Lopez, L. V. & Salic, A. J. Cell Biol. 191, 415–428 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Jeremy F. Reiter.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kumar, D., Reiter, J.F. A kinesin mimics DNA. Nat Cell Biol 24, 1015–1016 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing