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Intrinsically disordered CO2 sensors

Intrinsically disordered regions are a ubiquitous class of protein domains that lack a fixed 3D structure. Here, an evolutionarily conserved family of disordered CO2 sensors has been discovered, expanding the growing repertoire of disordered regions that respond to changes in the cellular environment.

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Fig. 1: An IDR-dependent CO2 sensor.


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Correspondence to Alex S. Holehouse.

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Competing interests

A.S.H. is a scientific consultant with Dewpoint Therapeutics. R.J.E. has no competing interests.

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Emenecker, R.J., Holehouse, A.S. Intrinsically disordered CO2 sensors. Nat Cell Biol 24, 1013–1014 (2022).

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