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Don’t put all your epigenetic eggs in one basket

In Caenorhabditis elegans, RNAi-initiated gene silencing can persist for multiple generations. A study shows that this heritable silencing requires parallel contributions of both a nuclear transcriptional silencing pathway and perinuclear condensate-localized poly(UG)-tailed transcripts to produce abundant germline siRNAs in adult progeny.

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Fig. 1: Complementary HRDE-1- and ZNFX-1-dependent heritable RNAi.


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Correspondence to Craig P. Hunter.

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N.M.B. and C.P.H. declare no competing interests.

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Bush, N.M., Hunter, C.P. Don’t put all your epigenetic eggs in one basket. Nat Cell Biol 24, 1016–1018 (2022).

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