The mechanisms that underlie cell identity remain poorly understood. A study now dissects the transcriptional trajectories of single cells undergoing malignant transformation or reprogramming to pluripotency and reveals regulators of cell plasticity in these biological processes.
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B.D.S. is grateful to J. Brumbaugh, M. Hoetker, J. Lee, R. J. Parchem, J. L. Sardina and members of the Di Stefano laboratory for critical reading of the manuscript. Research in the Di Stefano laboratory is supported by a Cancer Prevention & Research Institute of Texas Recruitment of First-Time, Tenure-Track Faculty Member Award (RR200079), an American Society of Hematology Scholar Award, a Milky Way Research Foundation Investigator Award, and a Nancy Chang, PhD Award for Research Excellence. B.D.S. is a CPRIT Scholar in Cancer Research.
The author declares no competing interests.
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Di Stefano, B. Cell identity and plasticity uncoupled. Nat Cell Biol 24, 1326–1327 (2022). https://doi.org/10.1038/s41556-022-00943-7