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STEM CELLS

Cell identity and plasticity uncoupled

The mechanisms that underlie cell identity remain poorly understood. A study now dissects the transcriptional trajectories of single cells undergoing malignant transformation or reprogramming to pluripotency and reveals regulators of cell plasticity in these biological processes.

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Fig. 1: Determinants of cell plasticity revealed.

References

  1. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    CAS  PubMed  Google Scholar 

  2. Wang, H., Yang, Y., Liu, J. & Qian, L. Nat. Rev. Mol. Cell Biol. 22, 410–424 (2021).

    Article  Google Scholar 

  3. Suva, M. L., Riggi, N. & Bernstein, B. E. Science 339, 1567–1570 (2013).

    Article  CAS  Google Scholar 

  4. Brumbaugh, J., Di Stefano, B. & Hochedlinger, K. Development 146, dev182170 (2019).

    Article  CAS  Google Scholar 

  5. Huyghe, A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00986-w (2022).

  6. Deng, W., Jacobson, E. C., Collier, A. J. & Plath, K. Curr. Opin. Genet. Dev. 70, 89–96 (2021).

    Article  CAS  Google Scholar 

  7. Ischenko, I., Zhi, J., Moll, U. M., Nemajerova, A. & Petrenko, O. Proc. Natl Acad. Sci. USA 110, 3937–3942 (2013).

    Article  CAS  Google Scholar 

  8. Kong, W. et al. Cell Stem Cell 29, 635–649 (2022).

    Article  CAS  Google Scholar 

  9. Li, P. et al. Science 329, 85–89 (2010).

    Article  CAS  Google Scholar 

  10. Ge, Y. & Fuchs, E. Nat. Rev. Genet. 19, 311–325 (2018).

    Article  CAS  Google Scholar 

  11. Quintanal-Villalonga, A. et al. Nat. Rev. Clin. Oncol. 17, 360–371 (2020).

    Article  Google Scholar 

  12. Lennon, M. J., Jones, S. P., Lovelace, M. D., Guillemin, G. J. & Brew, B. J. Front. Cell Neurosci. 11, 89 (2017).

    Article  Google Scholar 

Download references

Acknowledgements

B.D.S. is grateful to J. Brumbaugh, M. Hoetker, J. Lee, R. J. Parchem, J. L. Sardina and members of the Di Stefano laboratory for critical reading of the manuscript. Research in the Di Stefano laboratory is supported by a Cancer Prevention & Research Institute of Texas Recruitment of First-Time, Tenure-Track Faculty Member Award (RR200079), an American Society of Hematology Scholar Award, a Milky Way Research Foundation Investigator Award, and a Nancy Chang, PhD Award for Research Excellence. B.D.S. is a CPRIT Scholar in Cancer Research.

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Correspondence to Bruno Di Stefano.

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Di Stefano, B. Cell identity and plasticity uncoupled. Nat Cell Biol 24, 1326–1327 (2022). https://doi.org/10.1038/s41556-022-00943-7

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