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PRC2 shields the potency of human stem cells

Human naive pluripotent stem cells are generally believed to possess an unrestricted capacity to differentiate into both embryonic and extraembryonic lineages. However, two new studies now uncover a role for the Polycomb repressive complex 2 (PRC2) as a lineage gatekeeper that shields the potency of these cells.

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Fig. 1: The role of PRC2 in the differentiation of naive hPS cells.


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Correspondence to Sergi Aranda or Luciano Di Croce.

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Aranda, S., Condemi, L. & Di Croce, L. PRC2 shields the potency of human stem cells. Nat Cell Biol 24, 806–808 (2022).

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