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CELL DEATH IN CANCER

Stress response regulates cancer fibroblasts

Fibroblasts become activated during wound repair and rapidly return to a ‘resting’ state, and are thus critical for normal tissue homeostasis and tumour development. A new study now reveals an important pro-tumorigenic role for the stress response in cancer-associated fibroblasts that may offer a new opportunity to limit tumour progression.

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Fig. 1: ATF4 is the executioner transcription factor of ISR signalling.

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Correspondence to Sheila A. Stewart.

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Faget, D.V., Stewart, S.A. Stress response regulates cancer fibroblasts. Nat Cell Biol 24, 812–814 (2022). https://doi.org/10.1038/s41556-022-00930-y

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