Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

REGENERATION

Defining the pathways of heart regeneration

Although cardiac cell therapy has been intensely studied, the high expectations are still an unmet goal. A study now characterizes the translational potential and mode of action of human ventricular progenitors (HVPs) derived from embryonic stem cells, as a source for cardiac cell therapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The proposed mode of action of HVP-mediated cardiac cell therapy.

References

  1. Menasché, P. et al. Lancet 357, 279–280 (2001).

    Article  Google Scholar 

  2. Nguyen, P. K., Rhee, J. W. & Wu, J. C. JAMA Cardiol. 1, 831–841 (2016).

    Article  Google Scholar 

  3. Nat. Biotechnol. 35, 291 (2017).

  4. Madonna, R. et al. Eur. Heart J. 37, 1789–1798 (2016).

    Article  Google Scholar 

  5. Cai, C. L. & Molkentin, J. D. Circ. Res. 120, 400–406 (2017).

    Article  CAS  Google Scholar 

  6. Zwetsloot, P. P. et al. Circ. Res. 118, 1223–1232 (2016).

    Article  CAS  Google Scholar 

  7. Vagnozzi, R. J. et al. Nature 577, 405–409 (2020).

    Article  CAS  Google Scholar 

  8. Foo, K. S. et al. Mol. Ther. 26, 1644–1659 (2018).

    Article  CAS  Google Scholar 

  9. Poch, C. M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00899-8 (2022).

  10. Farbehi, N. et al. eLife 8, e43882 (2019).

    Article  Google Scholar 

  11. Molenaar, B. & van Rooij, E. Circ. Res. 123, 1033–1035 (2018).

    Article  CAS  Google Scholar 

  12. Chong, J. J. et al. Nature 510, 273–277 (2014).

    Article  CAS  Google Scholar 

  13. Shiba, Y. et al. Nature 538, 388–391 (2016).

    Article  CAS  Google Scholar 

  14. Liu, Y. W. et al. Nat. Biotechnol. 36, 597–605 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eva van Rooij.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Timmer, L.T., van Rooij, E. Defining the pathways of heart regeneration. Nat Cell Biol 24, 606–607 (2022). https://doi.org/10.1038/s41556-022-00914-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-022-00914-y

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing