Although cardiac cell therapy has been intensely studied, the high expectations are still an unmet goal. A study now characterizes the translational potential and mode of action of human ventricular progenitors (HVPs) derived from embryonic stem cells, as a source for cardiac cell therapy.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Menasché, P. et al. Lancet 357, 279–280 (2001).
Nguyen, P. K., Rhee, J. W. & Wu, J. C. JAMA Cardiol. 1, 831–841 (2016).
Nat. Biotechnol. 35, 291 (2017).
Madonna, R. et al. Eur. Heart J. 37, 1789–1798 (2016).
Cai, C. L. & Molkentin, J. D. Circ. Res. 120, 400–406 (2017).
Zwetsloot, P. P. et al. Circ. Res. 118, 1223–1232 (2016).
Vagnozzi, R. J. et al. Nature 577, 405–409 (2020).
Foo, K. S. et al. Mol. Ther. 26, 1644–1659 (2018).
Poch, C. M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00899-8 (2022).
Farbehi, N. et al. eLife 8, e43882 (2019).
Molenaar, B. & van Rooij, E. Circ. Res. 123, 1033–1035 (2018).
Chong, J. J. et al. Nature 510, 273–277 (2014).
Shiba, Y. et al. Nature 538, 388–391 (2016).
Liu, Y. W. et al. Nat. Biotechnol. 36, 597–605 (2018).
The authors declare no competing interests.
About this article
Cite this article
Timmer, L.T., van Rooij, E. Defining the pathways of heart regeneration. Nat Cell Biol 24, 606–607 (2022). https://doi.org/10.1038/s41556-022-00914-y