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AGEING

Long life depends on open communication

Nature Cell Biology volume 24, pages 808–810 (2022)Cite this article

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The lysosome is an essential organelle that degrades extra- and intra-cellular components and acts as a signaling hub. A study in Caenorhabditis elegans now shows that the lysosome mediates inter-tissue communication from periphery to neurons to regulate lifespan via fatty acid breakdown and secretion.

Ageing is a complex process that results in organismal decline and death. The progressive loss of homeostasis during ageing occurs at multiple levels — cells, tissues, and organism. Understanding the mechanisms that regulate lifespan could identify ways of slowing, and perhaps reversing, the ageing process. Organelles, such as the lysosome, have been shown to maintain cellular and organismal homeostasis during ageing1. In this issue of Nature Cell Biology, Savini et al.2 find that the lysosome is critical in regulating lipid signals from peripheral tissues to neurons to regulate whole organism longevity.

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Fig. 1: Lysosomal lipid signaling from intestine to neurons for longevity regulation.

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Authors and Affiliations

  1. Department of Genetics, Stanford University, Stanford, CA, USA

    Jason Wayne Miklas & Anne Brunet

  2. Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA, USA

    Anne Brunet

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  1. Jason Wayne Miklas
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  2. Anne Brunet
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Correspondence to Anne Brunet.

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The authors declare no competing interests.

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Miklas, J.W., Brunet, A. Long life depends on open communication. Nat Cell Biol 24, 808–810 (2022). https://doi.org/10.1038/s41556-022-00908-w

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