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Long life depends on open communication

The lysosome is an essential organelle that degrades extra- and intra-cellular components and acts as a signaling hub. A study in Caenorhabditis elegans now shows that the lysosome mediates inter-tissue communication from periphery to neurons to regulate lifespan via fatty acid breakdown and secretion.

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Fig. 1: Lysosomal lipid signaling from intestine to neurons for longevity regulation.


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Correspondence to Anne Brunet.

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Miklas, J.W., Brunet, A. Long life depends on open communication. Nat Cell Biol 24, 808–810 (2022).

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