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A chosen STING with a PERKy trail

Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway signals by a non-canonical mechanism to control protein translation through the unfolded protein response sensor PERK, and thereby contributes to cellular senescence and organ fibrosis.

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Fig. 1: Signalling mechanism and function of non-canonical PERK activation by cGAS–STING at the ER to regulate mRNA translation.
Fig. 2: Pathological roles of the cGAS–STING pathway in organ-specific diseases.


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Funded by FONDECYT 1140549, ANID-FONDAP-15150012, ICM- P09-015-F (C.H.), and FONDECYT 3180427 (Y.H.).

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Correspondence to Claudio Hetz.

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The authors declare no competing interests.

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Hazari, Y., Hetz, C. A chosen STING with a PERKy trail. Nat Cell Biol 24, 602–604 (2022).

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