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A chosen STING with a PERKy trail

Nature Cell Biology volume 24, pages 602–604 (2022)Cite this article

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Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway signals by a non-canonical mechanism to control protein translation through the unfolded protein response sensor PERK, and thereby contributes to cellular senescence and organ fibrosis.

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Fig. 1: Signalling mechanism and function of non-canonical PERK activation by cGAS–STING at the ER to regulate mRNA translation.
Fig. 2: Pathological roles of the cGAS–STING pathway in organ-specific diseases.

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Acknowledgements

Funded by FONDECYT 1140549, ANID-FONDAP-15150012, ICM- P09-015-F (C.H.), and FONDECYT 3180427 (Y.H.).

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Authors and Affiliations

  1. Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile

    Younis Hazari & Claudio Hetz

  2. FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile

    Claudio Hetz

  3. Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile

    Claudio Hetz

  4. Buck Institute for Research on Aging, Novato, CA, USA

    Claudio Hetz

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  1. Younis Hazari
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  2. Claudio Hetz
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Correspondence to Claudio Hetz.

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Hazari, Y., Hetz, C. A chosen STING with a PERKy trail. Nat Cell Biol 24, 602–604 (2022). https://doi.org/10.1038/s41556-022-00905-z

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