Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

PROTEIN AGGREGATION

Centrosomes grow aggresomes to clear waste

Overload of proteasomal clearance triggers formation of a large protein inclusion called the aggresome, which shares similarities with protein aggregates seen in neurodegenerative diseases such as Huntington’s. A new study uncovers how centrosome and centriolar satellite components facilitate stepwise assembly of aggresomes.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Models for CP110 and centriolar satellite function in aggresome assembly and in pathological protein aggregation.

References

  1. Douglas, P. M. & Dillin, A. J. Cell Biol. 190, 719–729 (2010).

    CAS  Article  Google Scholar 

  2. Johnston, H. E. & Samant, R. S. FEBS J. 288, 4464–4487 (2021).

    CAS  Article  Google Scholar 

  3. Johnston, J. A., Ward, C. L. & Kopito, R. R. J. Cell Biol. 143, 1883–98 (1998).

    CAS  Article  Google Scholar 

  4. Tischer, J., Carden, S. & Gergely, F. Curr. Opin. Struct. Biol. 66, 148–155 (2021).

    CAS  Article  Google Scholar 

  5. Prosser, S. L. et al. Nat Cell Biol. https://doi.org/10.1038/s41556-022-00869-0 (2022).

    Article  PubMed  Google Scholar 

  6. Didier, C., Merdes, A., Gairin, J.-E. & Jabrane-Ferrat, N. Mol. Biol. Cell 19, 1220–1229 (2008).

    CAS  Article  Google Scholar 

  7. Kawaguchi, Y. et al. Cell 115, 727–738 (2003).

    CAS  Article  Google Scholar 

  8. Fortun, J., Dunn, W. A., Joy, S., Li, J. & Notterpek, L. J. Neurosci. 23, 10672–10680 (2003).

    CAS  Article  Google Scholar 

  9. Schmidt, T. I. et al. Curr. Biol. 19, 1005–1011 (2009).

    CAS  Article  Google Scholar 

  10. Spektor, A., Tsang, W. Y., Khoo, D. & Dynlacht, B. D. Cell 130, 678–690 (2007).

    CAS  Article  Google Scholar 

  11. Tsang, W. Y. et al. Dev. Cell 15, 187–197 (2008).

    CAS  Article  Google Scholar 

  12. Choi, W. H. et al. Proc Natl Acad. Sci. USA 117, 19190–19200 (2020).

    CAS  Article  Google Scholar 

  13. Bobrowska, A., Paganetti, P., Matthias, P. & Bates, G. P. PLoS ONE 6, e20696 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fanni Gergely.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vitiello, E., Gergely, F. Centrosomes grow aggresomes to clear waste. Nat Cell Biol 24, 408–410 (2022). https://doi.org/10.1038/s41556-022-00891-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-022-00891-2

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing