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Centrosomes grow aggresomes to clear waste

Overload of proteasomal clearance triggers formation of a large protein inclusion called the aggresome, which shares similarities with protein aggregates seen in neurodegenerative diseases such as Huntington’s. A new study uncovers how centrosome and centriolar satellite components facilitate stepwise assembly of aggresomes.

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Fig. 1: Models for CP110 and centriolar satellite function in aggresome assembly and in pathological protein aggregation.


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Correspondence to Fanni Gergely.

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Vitiello, E., Gergely, F. Centrosomes grow aggresomes to clear waste. Nat Cell Biol 24, 408–410 (2022).

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