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MEMBRANE DYNAMICS

Phosphoinositide phosphorylation sans kinase

Phosphoinositide signalling regulates cellular processes and is hijacked by pathogens. Classically, phosphoinositides are produced by kinase- and phosphatase-catalysed reactions. A study now reveals an unprecedented, kinase- and ATP-free synthesis of PtdIns(3,4)P2 via a phosphotransferase mechanism during bacterial infection.

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Fig. 1: Kinase- and ATP-independent PtdIns(3,4)P2 generation from PtdIns(4,5)P2 by the bacterial effector SopB.

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Correspondence to Jeremy M. Baskin.

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Cao, X., Baskin, J.M. Phosphoinositide phosphorylation sans kinase. Nat Cell Biol 24, 604–606 (2022). https://doi.org/10.1038/s41556-022-00885-0

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