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CANCER

Navigating EMT with COMPASS and PRC2

Epithelial to mesenchymal transitions (EMTs) drive cancer metastases. A series of single cell analyses now reveal this change in state is not binary and that two epigenetic complexes govern the convertibility of epithelial cells to mesenchymal states that are differentially conducive to metastasis.

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Fig. 1: Schematic representation of the activation of distinct EMT paths after the loss of function of chromatin-modifying complexes.

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Correspondence to Evangelia Koutelou or Sharon Y. R. Dent.

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Koutelou, E., Dent, S.Y.R. Navigating EMT with COMPASS and PRC2. Nat Cell Biol 24, 412–414 (2022). https://doi.org/10.1038/s41556-022-00876-1

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