Haematopoiesis is a process relying on haematopoietic stem cells (HSCs) and their complex interactions with the microenvironment. A new study by Pinho et al. identifies the adhesion molecule VCAM1 as an immune checkpoint that protects haematopoietic stem and progenitor cells, as well as leukaemic cells, from monocytic phagocytosis.
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Stanger, A.M.P., Lengerke, C. VCAM1 as a don’t-eat-me molecule. Nat Cell Biol 24, 282–283 (2022). https://doi.org/10.1038/s41556-022-00864-5
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DOI: https://doi.org/10.1038/s41556-022-00864-5
