Tumour growth involves anomalies in cell cycle genes and emergent phenotypes, but the tumour proliferation rate (or mitotic index) is defined by just one marker, Ki-67. A study now integrates expression patterns of several markers to generate spatio-temporal maps of cell proliferation in cancer tissues.
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Kumar-Sinha, C., Chinnaiyan, A.M. Defining cancer growth beyond the mitotic index. Nat Cell Biol 24, 285–287 (2022). https://doi.org/10.1038/s41556-022-00862-7
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DOI: https://doi.org/10.1038/s41556-022-00862-7