Extracellular matrix (ECM) rigidity increases during tumour progression. In a recent study, Romani et al. delineated a connection between ECM stiffness and the redox response of disseminated tumour cells. Their results suggest that soft ECM promotes DRP1-mediated mitochondrial fission and an NRF2-dependent antioxidant response.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Romani, P. et al. Nat. Cell. Biol. https://doi.org/10.1038/s41556-022-00843-w (2022).
Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J. & Werb, Z. Nat. Commun. 11, 5120 (2020).
Klein, S. Am. Fam. Physician 71, 1731–1738 (2005).
Hayashi, M. et al. Ann. Surg. Oncol. 19, 3042–3049 (2012).
Jing, H. et al. J. Ultrasound Med. 35, 1619–1627 (2016).
Paszek, M. J. et al. Cancer Cell 8, 241–254 (2005).
Sosa, M. S., Bragado, P. & Aguirre-Ghiso, J. A. Nat. Rev. Cancer 14, 611–622 (2014).
Tharp, K. M. et al. Cell Metab. 33, 1322–1341.e1313 (2021).
Helle, S. C. J. et al. eLife 6, e30292 (2017).
Piskounova, E. et al. Nature 527, 186–191 (2015).
Carreau, A., El Hafny-Rahbi, B., Matejuk, A., Grillon, C. & Kieda, C. J. Cell. Mol. Med. 15, 1239–1253 (2011).
Yu, T., Robotham, J. L. & Yoon, Y. Proc. Natl Acad. Sci. USA 103, 2653–2658 (2006).
Tonelli, C., Chio, I. I. C. & Tuveson, D. A. Antioxid. Redox Signal. 29, 1727–1745 (2018).
Sabouny, R. et al. Antioxid. Redox Signal. 27, 1447–1459 (2017).
Cvetko, F. et al. J. Biol. Chem. 296, 100169 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests
Rights and permissions
About this article
Cite this article
Powers, J.A., Chio, I.I.C. Softening redox homeostasis in cancer cells. Nat Cell Biol 24, 133–134 (2022). https://doi.org/10.1038/s41556-022-00845-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-022-00845-8