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Positive feedback amplifies ferroptosis


Lipid metabolism is crucial for the execution of ferroptosis. A new study demonstrates that the function of the lipid metabolic enzyme ACSL4 is positively regulated by phosphorylation, leading to amplification of ferroptotic cell death. These results shed new light on the regulation of ferroptosis execution in cancer cells.

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Fig. 1: Feedforward mechanism of PUFA regulation.


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Correspondence to Scott J. Dixon.

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Competing interests

S.J.D. is a founder of Prothegen Inc., is a member of the scientific advisory boards for Ferro Therapeutics and Hillstream Biopharma, and holds patents related to ferroptosis. J.R. declares no competing interests.

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Rodencal, J., Dixon, S.J. Positive feedback amplifies ferroptosis. Nat Cell Biol 24, 4–5 (2022).

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