Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NUCLEAR TRANSPORT

Mapping paths through the nuclear pore complex

Nature Cell Biology volume 24, pages 6–7 (2022)Cite this article

Subjects

An Author Correction to this article was published on 08 February 2022

This article has been updated

Nuclear pore complexes (NPCs) facilitate the fast, yet highly selective, nucleocytoplasmic transport of molecules. A recent study describes a multicolour imaging approach to chart the paths for cargo molecules through the human NPC with real-time 3D visualization of nucleocytoplasmic transport events with high spatial and temporal precision.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: NTRs distribution within the NPC.

Change history

References

  1. Lin, D. H. & Hoelz, A. Annu. Rev. Biochem. 88, 725–783 (2019).

    Article  CAS  Google Scholar 

  2. Hampoelz, B. et al. Annu. Rev. Biophys. 48, 515–536 (2019).

    Article  CAS  Google Scholar 

  3. Fernandez-Martinez, J. & Rout, M. P. Trends Biochem. Sci. 46, 595–607 (2021).

    Article  CAS  Google Scholar 

  4. Chowdhury, R., Sau, A. & Musser, S. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00815-6 (2021).

  5. Dickmanns, A., Kehlenbach, R. H. & Fahrenkrog, B. Int. Rev. Cell Mol. Biol. 320, 171–233 (2015).

    Article  CAS  Google Scholar 

  6. Coyne, A. N. et al. Neuron 107, 1124–1140 (2020).

    Article  CAS  Google Scholar 

  7. Paine, P. L., Moore, L. C. & Horowitz, S. B. Nature 254, 109114 (1975).

    Article  Google Scholar 

  8. Ribbeck, K. & Gorlich, D. EMBO J. 20, 1320–1330 (2001).

    Article  CAS  Google Scholar 

  9. Schuller, A. P. et al. Nature 598, 667–671 (2021).

    Article  CAS  Google Scholar 

  10. Kapinos, L. E. et al. J. Cell Biol. 216, 3609–3624 (2017).

    Article  CAS  Google Scholar 

  11. Zimmerli, C. E. et al. Science https://doi.org/10.1126/science.abd9776 (2021).

  12. Mackmull, M. T. et al. Mol. Syst. Biol. 13, 962 (2017).

    Article  Google Scholar 

  13. Paci, G., Caria, J. & Lemke, E. A. J. Cell Sci. 134, jcs247874 (2021).

    Article  CAS  Google Scholar 

  14. Dasso, M. Curr. Biol. 12, R502–R508 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Figure 1 was created using BioRender and Microsoft PowerPoint software.

Author information

Authors and Affiliations

  1. Division of Molecular and Cellular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    Vasilisa Aksenova & Mary Dasso

Authors
  1. Vasilisa Aksenova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mary Dasso
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vasilisa Aksenova.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aksenova, V., Dasso, M. Mapping paths through the nuclear pore complex. Nat Cell Biol 24, 6–7 (2022). https://doi.org/10.1038/s41556-021-00823-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-021-00823-6

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing