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Surveying the mitochondrial proteome

Mitochondrial-derived vesicles (MDVs) transfer mitochondrial content to lysosomes and peroxisomes. A study now reveals that MDVs deliver β-barrel proteins and fully assembled mitochondrial complexes for lysosomal degradation, establishing an important role for MDVs in mitochondrial protein quality control.

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Fig. 1: Function and formation of MDVs.

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References

  1. Song, J., Herrmann, J. M. & Becker, T. Nat. Rev. Mol. Cell Biol. 22, 54–70 (2021).

    Article  CAS  Google Scholar 

  2. König, T. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00798-4 (2021).

  3. Soubannier, V. et al. Curr. Biol. 22, 135–141 (2012).

    Article  CAS  Google Scholar 

  4. Neuspiel, M. et al. Curr. Biol. 18, 102–108 (2008).

    Article  CAS  Google Scholar 

  5. McLelland, G. L. et al. EMBO J. 33, 282–295 (2014).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. McLelland, G. L. et al. J. Cell Biol. 214, 275–291 (2016).

    Article  CAS  Google Scholar 

  7. Suguira, A. et al. Nature 542, 251–254 (2017).

    Article  Google Scholar 

  8. Matheoud, D. et al. Cell 166, 314–327 (2016).

    Article  CAS  Google Scholar 

  9. Hughes, A. L. et al. eLife 5, e13943 (2016).

    Article  Google Scholar 

  10. Schuler, M. H. et al. Mol. Cell 81, 3786–3802 (2021).

    Article  CAS  Google Scholar 

  11. Phu, L. et al. Mol. Cell 77, 1107–1123 (2020).

    Article  CAS  Google Scholar 

  12. Adachi, Y. et al. Mol. Cell 63, 1034–1043 (2016).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Thomas Becker.

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Winter, D., Becker, T. Surveying the mitochondrial proteome. Nat Cell Biol 23, 1216–1217 (2021). https://doi.org/10.1038/s41556-021-00801-y

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