Mitochondrial-derived vesicles (MDVs) transfer mitochondrial content to lysosomes and peroxisomes. A study now reveals that MDVs deliver β-barrel proteins and fully assembled mitochondrial complexes for lysosomal degradation, establishing an important role for MDVs in mitochondrial protein quality control.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
biorender.com.
References
Song, J., Herrmann, J. M. & Becker, T. Nat. Rev. Mol. Cell Biol. 22, 54–70 (2021).
König, T. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00798-4 (2021).
Soubannier, V. et al. Curr. Biol. 22, 135–141 (2012).
Neuspiel, M. et al. Curr. Biol. 18, 102–108 (2008).
McLelland, G. L. et al. EMBO J. 33, 282–295 (2014).
McLelland, G. L. et al. J. Cell Biol. 214, 275–291 (2016).
Suguira, A. et al. Nature 542, 251–254 (2017).
Matheoud, D. et al. Cell 166, 314–327 (2016).
Hughes, A. L. et al. eLife 5, e13943 (2016).
Schuler, M. H. et al. Mol. Cell 81, 3786–3802 (2021).
Phu, L. et al. Mol. Cell 77, 1107–1123 (2020).
Adachi, Y. et al. Mol. Cell 63, 1034–1043 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Winter, D., Becker, T. Surveying the mitochondrial proteome. Nat Cell Biol 23, 1216–1217 (2021). https://doi.org/10.1038/s41556-021-00801-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-021-00801-y
