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WAVE complex regulation by force

The WAVE regulatory complex is well known as an orchestrator of actin dynamics at the leading edge of migrating cells. A recent study shows how mechanical effects can regulate the WAVE complex and explains the importance of forces generated by actin filaments to control new actin generation at the leading edge.

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Fig. 1: The WRC diffuses laterally on the plasma membrane and is captured at the leading edge.


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Correspondence to Laura M. Machesky.

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Machesky, L.M., Insall, R.H. WAVE complex regulation by force. Nat Cell Biol 23, 1111–1112 (2021).

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