The WAVE regulatory complex is well known as an orchestrator of actin dynamics at the leading edge of migrating cells. A recent study shows how mechanical effects can regulate the WAVE complex and explains the importance of forces generated by actin filaments to control new actin generation at the leading edge.
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Machesky, L.M., Insall, R.H. WAVE complex regulation by force. Nat Cell Biol 23, 1111–1112 (2021). https://doi.org/10.1038/s41556-021-00790-y
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DOI: https://doi.org/10.1038/s41556-021-00790-y
