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An RNA helicase swirls in lymphangiogenesis

How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

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Fig. 1: Discovery, mechanism and implications for the new findings on the role of Ddx21 in lymphangiogenesis.


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Correspondence to Rui Benedito.

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Mühleder, S., Benedito, R. An RNA helicase swirls in lymphangiogenesis. Nat Cell Biol 23, 1109–1110 (2021).

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