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An RNA helicase swirls in lymphangiogenesis

Nature Cell Biology volume 23, pages 1109–1110 (2021)Cite this article

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How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

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Fig. 1: Discovery, mechanism and implications for the new findings on the role of Ddx21 in lymphangiogenesis.

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Authors and Affiliations

  1. Molecular Genetics of Angiogenesis Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

    Severin Mühleder & Rui Benedito

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  1. Severin Mühleder
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  2. Rui Benedito
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Correspondence to Rui Benedito.

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The authors declare no competing interests.

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Mühleder, S., Benedito, R. An RNA helicase swirls in lymphangiogenesis. Nat Cell Biol 23, 1109–1110 (2021). https://doi.org/10.1038/s41556-021-00789-5

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