How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.
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The authors declare no competing interests.
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Mühleder, S., Benedito, R. An RNA helicase swirls in lymphangiogenesis. Nat Cell Biol 23, 1109–1110 (2021). https://doi.org/10.1038/s41556-021-00789-5