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Epigenetic remodelling upon FGFR inhibition

Nature Cell Biology volume 23, pages 1115–1116 (2021)Cite this article

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FGFR-altered triple negative breast cancer (TNBC) develops adaptive resistance to FGFR inhibitor therapy. A new study shows that sustained FGFR inhibition causes SWI/SNF complex eviction at YAP-recruited enhancers followed by increased mTORC1 activity. Dual inhibition of YAP or mTORC1 and FGFR has a synergistic effect on tumour growth.

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Fig. 1: Model of epigenetic remodelling after prolonged FGFR inhibition.

References

  1. Li, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00781-z (2021).

  2. Skibinski, A. et al. Cell Rep. 6, 1059–1072 (2014).

    Article  CAS  Google Scholar 

  3. Orlando, K. A. et al. eLife 9, e59073 (2020).

    Article  CAS  Google Scholar 

  4. Zanconato, F. et al. Nat. Cell Biol. 17, 1218–1227 (2015).

    Article  CAS  Google Scholar 

  5. Vierbuchen, T. et al. Mol. Cell 68, 1067–1082.e12 (2017).

    Article  CAS  Google Scholar 

  6. Oberlick, E. M. et al. Cell Rep. 28, 2331–2344.e8 (2019).

    Article  CAS  Google Scholar 

  7. Lang, J. D. et al. Clin. Cancer Res. 24, 1932–1943 (2018).

    Article  CAS  Google Scholar 

  8. Chauvin, C. et al. Cell Rep. 21, 1737–1745 (2017).

    Article  CAS  Google Scholar 

  9. Wong, J. P. et al. Cell Rep. 17, 1265–1275 (2016).

    Article  CAS  Google Scholar 

  10. Miller, R. E. et al. Mol. Cancer Ther. 15, 1472–1484 (2016).

    Article  CAS  Google Scholar 

  11. Wöhrle, S. et al. PLoS One 8, e77652 (2013).

    Article  Google Scholar 

  12. Chang, L. et al. Nature 563, 265–269 (2018).

    Article  CAS  Google Scholar 

  13. Wu, Q. et al. Epigenomics 9, 919–931 (2017).

    Article  CAS  Google Scholar 

  14. Wu, Q. et al. Oncotarget 7, 27158–27175 (2016).

    Article  Google Scholar 

  15. Alver, B. H. et al. Nat. Commun. 8, 14648 (2017).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Science, Research Triangle Park, NC, USA

    Krystal A. Orlando & Paul A. Wade

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  1. Krystal A. Orlando
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  2. Paul A. Wade
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Correspondence to Paul A. Wade.

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The authors declare no competing interests.

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Orlando, K.A., Wade, P.A. Epigenetic remodelling upon FGFR inhibition. Nat Cell Biol 23, 1115–1116 (2021). https://doi.org/10.1038/s41556-021-00782-y

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