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Metabolites control stress granule disassembly

Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reveal how proteins can directly sense the cellular energy state to facilitate adaptive reorganization.

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Fig. 1: Cdc19 senses metabolic state to regulate stress granule assembly.


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Correspondence to Daniel F. Jarosz.

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Jakobson, C.M., Jarosz, D.F. Metabolites control stress granule disassembly. Nat Cell Biol 23, 1053–1055 (2021).

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