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METABOLISM

Metabolites control stress granule disassembly

Nature Cell Biology volume 23, pages 1053–1055 (2021)Cite this article

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Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reveal how proteins can directly sense the cellular energy state to facilitate adaptive reorganization.

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Fig. 1: Cdc19 senses metabolic state to regulate stress granule assembly.

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Authors and Affiliations

  1. Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA

    Christopher M. Jakobson & Daniel F. Jarosz

  2. Department of Developmental Biology, Stanford University, Stanford, CA, USA

    Daniel F. Jarosz

Authors
  1. Christopher M. Jakobson
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  2. Daniel F. Jarosz
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Correspondence to Daniel F. Jarosz.

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The authors declare no competing interests.

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Jakobson, C.M., Jarosz, D.F. Metabolites control stress granule disassembly. Nat Cell Biol 23, 1053–1055 (2021). https://doi.org/10.1038/s41556-021-00768-w

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