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IMMUNOLOGY

Eosinophils set DNA traps in allergic asthma

The underlying molecular and cellular mechanisms for asthma remain incompletely understood. A new study now shows that eosinophils release DNA traps that stimulate pulmonary neuroendocrine cell-mediated amplification of the allergic asthma response.

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Fig. 1: Allergen EET release by eosinophils reinforces PNEC-mediated type 2 immunity.

References

  1. 1.

    Hammad, H. & Lambrecht, B. N. Cell 184, 1469–1485 (2021).

    CAS  Article  Google Scholar 

  2. 2.

    Lu, Y., Huang, Y. & Li, J. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00762-2 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Lee, J. J. et al. Science 305, 1773–1776 (2004).

    CAS  Article  Google Scholar 

  4. 4.

    Humbles, A. A. et al. Science 305, 1776–1779 (2004).

    CAS  Article  Google Scholar 

  5. 5.

    Jacobsen, E. A. et al. Annu. Rev. Immunol. 39, 719–757 (2021).

    CAS  Article  Google Scholar 

  6. 6.

    Papayannopoulos, V. Nat. Rev. Immunol. 18, 134–147 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Ehrens, A. et al. Cell Rep. 34, 108621 (2021).

    CAS  Article  Google Scholar 

  8. 8.

    Hull, J. H. K., Castle, N., Knight, R. K. & Ho, T. B. L. Resuscitation 74, 175–177 (2007).

    CAS  Article  Google Scholar 

  9. 9.

    Chia, A. C. L., Menzies, D. & McKeon, D. J. BMJ Case Rep. 2013, bcr2013009661 (2013).

    Google Scholar 

  10. 10.

    Wang, Y. i J. Cell Biol. 184, 205–213 (2009).

    CAS  Article  Google Scholar 

  11. 11.

    Y, W. et al. Science 306, 279–283 (2004).

    Article  Google Scholar 

  12. 12.

    Branchfield, K. et al. Science 351, 707–710 (2016).

    CAS  Article  Google Scholar 

  13. 13.

    Dash, B., Kim, E. & Sun, X. in Lung Stem Cells in Development, Health and Disease 44–55 (European Respiratory Society, 2021).

  14. 14.

    Sui, P. et al. Science 360, eaan8546 (2018).

    Article  Google Scholar 

  15. 15.

    Persson, E. K. et al. Science 364, eaaw4295 (2019).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Xin Sun.

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Dash, B., Sun, X. Eosinophils set DNA traps in allergic asthma. Nat Cell Biol 23, 1057–1059 (2021). https://doi.org/10.1038/s41556-021-00765-z

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