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CLICing on endocytic cargoes for cancer invasion

Clathrin- and dynamin-independent endocytosis is considered a major ‘default’ uptake route for cells, but a recent study describes the selective recruitment of integrin-adhesion receptor cargoes via the endocytic adaptor Swip1, which promotes breast cancer invasion and metastasis.

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Fig. 1: SWIP1 is a β1 integrin–specific cargo adaptor for the CG pathway.


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Correspondence to Patrick T. Caswell.

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Caswell, P.T. CLICing on endocytic cargoes for cancer invasion. Nat Cell Biol 23, 1052–1053 (2021).

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