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CLICing on endocytic cargoes for cancer invasion

Clathrin- and dynamin-independent endocytosis is considered a major ‘default’ uptake route for cells, but a recent study describes the selective recruitment of integrin-adhesion receptor cargoes via the endocytic adaptor Swip1, which promotes breast cancer invasion and metastasis.

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Fig. 1: SWIP1 is a β1 integrin–specific cargo adaptor for the CG pathway.

References

  1. Mayor, S., Parton, R. G. & Donaldson, J. G. Cold Spring Harb. Perspect. Biol. 6, a016758 (2014).

    Article  Google Scholar 

  2. Moreno-Layseca, P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00767-x (2021).

  3. Sigismund, S. & Scita, G. Curr. Opin. Cell Biol. 54, 9–17 (2018).

    Article  CAS  Google Scholar 

  4. Doherty, G. J. & McMahon, H. T. Annu. Rev. Biochem. 78, 857–902 (2009).

    Article  CAS  Google Scholar 

  5. Wilson, B. J., Allen, J. L. & Caswell, P. T. Traffic 19, 899–909 (2018).

    Article  CAS  Google Scholar 

  6. Renard, H. F. & Boucrot, E. Curr. Opin. Cell Biol. 71, 120–129 (2021).

    Article  CAS  Google Scholar 

  7. Kirkham, M. et al. J. Cell Biol. 168, 465–476 (2005).

    Article  CAS  Google Scholar 

  8. Howes, M. T. et al. J. Cell Biol. 190, 675–691 (2010).

    Article  CAS  Google Scholar 

  9. Sathe, M. et al. Nat. Commun. 9, 1–16 (2018).

    Article  CAS  Google Scholar 

  10. Traub, L. M. & Bonifacino, J. S. Cold Spring Harb. Perspect. Biol. 5, 1–23 (2013).

    Article  Google Scholar 

  11. Pellinen, T. et al. J. Cell Biol. 173, 767–780 (2006).

    Article  CAS  Google Scholar 

  12. Mosesson, Y., Mills, G. B. & Yarden, Y. Nat. Rev. Cancer 8, 835–850 (2008).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Patrick T. Caswell.

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Caswell, P.T. CLICing on endocytic cargoes for cancer invasion. Nat Cell Biol 23, 1052–1053 (2021). https://doi.org/10.1038/s41556-021-00763-1

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