Cell fate determination by H3.3 deposition in haematopoietic stem and progenitor cells is largely unexplored. Two studies jointly support the idea that H3.3 maintains haematopoiesis balance and prevents endogenous retroviral element (ERV) activation through chromatin marks and transcriptome alterations.
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Cipta, N.O., Chen, Y. & Loh, YH. H3.3 safeguards haematopoietic ERV-quilibrium. Nat Cell Biol 24, 7–9 (2022). https://doi.org/10.1038/s41556-021-00758-y
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DOI: https://doi.org/10.1038/s41556-021-00758-y