Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


An inflammatory switch for stem cell plasticity

Tissue-resident stem cells are capable of remarkable plasticity in areas of tissue damage, where inflammatory cells accumulate as part of the reparative response. A study in the lung now provides critical insight on how inflammatory signals alter cell-to-cell Notch signalling within the airway niche to drive stem cell plasticity.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Model of inflammation sensing in the stem cell niche that promotes airway secretory cell plasticity.


  1. 1.

    Basil, M. C. et al. Cell Stem Cell 26, 482–502 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Choi, J. et al. Nat. Cell Biol. 23, (2021).

  3. 3.

    Yuan, T. et al. Stem Cell Rep. 12, 1041–1055 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Cassandras, M. et al. Nat. Cell Biol. 22, 1295–1306 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Guseh, J. S. et al. Development 136, 1751–1759 (2009).

    CAS  Article  Google Scholar 

  6. 6.

    Rock, J. R. et al. Cell Stem Cell 8, 639–648 (2011).

    CAS  Article  Google Scholar 

  7. 7.

    Vaughan, A. E. et al. Nature 517, 621–625 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Xi, Y. et al. Nat. Cell Biol. 19, 904–914 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Katsura, H., Kobayashi, Y., Tata, P. R. & Hogan, B. L. M. Stem Cell Rep. 12, 657–666 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Lechner, A. J. et al. Cell Stem Cell 21, 120–134 (2017).

    CAS  Article  Google Scholar 

  11. 11.

    Choi, J. et al. Cell Stem Cell 27, 366–382 (2020).

    CAS  Article  Google Scholar 

  12. 12.

    Pardo-Saganta, A. et al. Nature 523, 597–601 (2015).

    CAS  Article  Google Scholar 

  13. 13.

    Lafkas, D. et al. Nature 528, 127–131 (2015).

    CAS  Article  Google Scholar 

  14. 14.

    Xu, Y. et al. JCI Insight 1, e90558 (2016).

    Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Tien Peng.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kathiriya, J.J., Peng, T. An inflammatory switch for stem cell plasticity. Nat Cell Biol 23, 928–929 (2021).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing