Stem cells are the functional units of tissue repair but do not act alone. Studies on flatworms now reveal specialized populations of differentiated cells that transiently emerge to coordinate whole-body regeneration. The stem-cell-centric view of repair processes must be revised to account for the importance of cell fate dynamics beyond the niche.
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Ellis, S.J., Fuchs, E. Stem cell progeny liaisons in regeneration. Nat Cell Biol 23, 932–933 (2021). https://doi.org/10.1038/s41556-021-00751-5
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DOI: https://doi.org/10.1038/s41556-021-00751-5
