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Stem cell progeny liaisons in regeneration

Stem cells are the functional units of tissue repair but do not act alone. Studies on flatworms now reveal specialized populations of differentiated cells that transiently emerge to coordinate whole-body regeneration. The stem-cell-centric view of repair processes must be revised to account for the importance of cell fate dynamics beyond the niche.

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Fig. 1: Identifying TRACS in planaria.


  1. Tanaka, E. M. & Reddien, P. W. Dev. Cell. 21, 172–185 (2011).

    Article  CAS  Google Scholar 

  2. Benham-Pyle, B. W. et al. Nat. Cell Biol. (2021).

  3. Morrison, S. J. & Spradling, A. Cell 132, 598–611 (2008).

    Article  CAS  Google Scholar 

  4. Xin, T., Greco, V. & Myung, P. Cell 164, 1212–1225 (2016).

    Article  CAS  Google Scholar 

  5. Winkler, I. G. et al. Blood 116, 4815–4828 (2010).

    Article  CAS  Google Scholar 

  6. Chow, A. et al. J. Exp. Med. 208, 261–271 (2011).

    Article  CAS  Google Scholar 

  7. Pardo-Saganta, A. et al. Nature 523, 597–601 (2015).

    Article  CAS  Google Scholar 

  8. Hsu, Y. C., Li, L. & Fuchs, E. Cell 157, 935–949 (2014).

    Article  CAS  Google Scholar 

  9. Hsu, Y. C., Pasolli, H. A. & Fuchs, E. Cell 144, 92–105 (2011).

    Article  CAS  Google Scholar 

  10. Reddien, P. W. Cell 175, 327–345 (2018).

    Article  CAS  Google Scholar 

  11. Petersen, C. P. & Reddien, P. W. Science 332, 852–855 (2011).

    Article  CAS  Google Scholar 

  12. Witchley, J. N. et al. Cell Rep. 4, 633–641 (2013).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Elaine Fuchs.

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Ellis, S.J., Fuchs, E. Stem cell progeny liaisons in regeneration. Nat Cell Biol 23, 932–933 (2021).

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