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CANCER

EZH2 accompanies prostate cancer progression

Enhancer of zeste homolog 2 (EZH2) has been shown to promote development of castration-resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that a phosphorylated EZH2 interacts with the androgen receptor (AR) and reprograms AR transcriptional activity to facilitate transition of CRPC into a lineage infidelity state.

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Fig. 1: EZH2 plays a multifaceted role in prostate cancer progression.

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Correspondence to Li Xin.

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Xin, L. EZH2 accompanies prostate cancer progression. Nat Cell Biol 23, 934–936 (2021). https://doi.org/10.1038/s41556-021-00744-4

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