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ASTE1 cutting to block DNA end resection

Cells rely on two main pathways to repair DNA lesions, homologous recombination and non-homologous end-joining, and how they decide to use one machinery over the other is not clear. A recent study identifies ASTE1 as a regulator controlling pathway choice.

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Fig. 1: Role of ASTE1 in DNA repair.


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Correspondence to Dipanjan Chowdhury.

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He, Y.J., Chowdhury, D. ASTE1 cutting to block DNA end resection. Nat Cell Biol 23, 818–819 (2021).

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