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Cancer

LKB1 cooperates with Sox17 to drive metastasis

LKB1 is frequently mutated in lung, cervical and other types of cancers. To determine how LKB1 inactivation contributes to lung cancer progression, Pierce et al. employed a chromatin accessibility assay to reveal Sox17 as a key transcription factor downstream of LKB1, promoting lung cancer metastasis.

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Fig. 1: LKB1 contribution to lung cancer progression and metastasis.

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Correspondence to Skirmantas Kriaucionis.

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Kriaucionis, S. LKB1 cooperates with Sox17 to drive metastasis. Nat Cell Biol 23, 816–817 (2021). https://doi.org/10.1038/s41556-021-00730-w

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