LKB1 is frequently mutated in lung, cervical and other types of cancers. To determine how LKB1 inactivation contributes to lung cancer progression, Pierce et al. employed a chromatin accessibility assay to reveal Sox17 as a key transcription factor downstream of LKB1, promoting lung cancer metastasis.
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Kriaucionis, S. LKB1 cooperates with Sox17 to drive metastasis. Nat Cell Biol 23, 816–817 (2021). https://doi.org/10.1038/s41556-021-00730-w
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DOI: https://doi.org/10.1038/s41556-021-00730-w
