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Mitochondrial UPR through generations

An Author Correction to this article was published on 16 September 2021

This article has been updated

Neuronal mitochondria perturbation elicits a mitochondrial unfolded protein response (UPRmt) in peripheral tissues cell non-autonomously, dependent on the Wnt signalling pathway. A study now reveals that a Wnt-mediated increase in maternally inherited mitochondria DNA is responsible for transgenerational UPRmt induced by neuronal mitochondria perturbation.

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Fig. 1: Transgenerational induction of UPRmt mediated by increased mtDNA levels.

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  1. 1.

    Baugh, L. R. & Day, T. eLife 9, e58498 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Perez, M. F. & Lehner, B. Nat. Cell Biol. 21, 143–151 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Moore, R. S., Kaletsky, R. & Murphy, C. T. Cell 177, 1827–1841.e2 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Klosin, A., Casas, E., Hidalgo-Carcedo, C., Vavouri, T. & Lehner, B. Science 356, 320–323 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Zhang, Q. et al. Nat. Cell Biol. (2021).

  6. 6.

    Shpilka, T. & Haynes, C. M. Nat. Rev. Mol. Cell Biol. 19, 109–120 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Berendzen, K. M. et al. Cell 166, 1553–1563.e10 (2016).

    CAS  Article  Google Scholar 

  8. 8.

    Zhang, Q. et al. Cell 174, 870–883.e17 (2018).

    CAS  Article  Google Scholar 

  9. 9.

    Gitschlag, B. L. et al. Cell Metab. 24, 91–103 (2016).

    CAS  Article  Google Scholar 

  10. 10.

    Lin, Y. F. et al. Nature 533, 416–419 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Nargund, A. M., Pellegrino, M. W., Fiorese, C. J., Baker, B. M. & Haynes, C. M. Science 337, 587–590 (2012).

    CAS  Article  Google Scholar 

  12. 12.

    Lee, S. S. et al. Nat. Genet. 33, 40–48 (2003).

    CAS  Article  Google Scholar 

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Correspondence to Meng C. Wang.

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Park, M., Wang, M.C. Mitochondrial UPR through generations. Nat Cell Biol 23, 820–821 (2021).

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