Lineage-specific gene expression programs in multicellular organisms are controlled by balanced ON and OFF signals, amongst which heterochromatin regulates expression by restricting activation cues. A study now provides insights into mammalian heterochromatin organisation, function and interplay with lineage-specific transcription factors.
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Burton, A., Torres-Padilla, ME. Deconfining heterochromatin for expression. Nat Cell Biol 23, 814–816 (2021). https://doi.org/10.1038/s41556-021-00726-6
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DOI: https://doi.org/10.1038/s41556-021-00726-6
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