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Membrane trafficking

The final twist in endocytic membrane scission

Many endocytic uptake events depend on the ‘pinchase’ activity of dynamin. By measuring the orientation of single gold nanorods, a new study reveals that invaginated clathrin-coated endocytic pits undergo a strong rotational twist prior to or concomitant with their detachment.

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Fig. 1: 3D-SPORT on dynamin’s function in endocytosis.

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Correspondence to Ludger Johannes.

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Johannes, L., Valades-Cruz, C.A. The final twist in endocytic membrane scission. Nat Cell Biol 23, 812–813 (2021). https://doi.org/10.1038/s41556-021-00711-z

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