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The ELOF(1)ant in the room of TCR

Transcription-coupled repair of DNA lesions takes place across all domains of life. A transcription-elongation factor, ELOF1, highly conserved in eukaryotes, has now been shown to play a key role in this process. Importantly, these findings also include evidence of a second transcription-coupled repair pathway in mammalian cells.

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Fig. 1: The role of ELOF1 in TC-NER.


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Correspondence to Stephen P. Jackson.

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Carnie, C.J., Jackson, S.P. The ELOF(1)ant in the room of TCR. Nat Cell Biol 23, 584–586 (2021).

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