Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DNA REPAIR

The ELOF(1)ant in the room of TCR

Nature Cell Biology volume 23, pages 584–586 (2021)Cite this article

Subjects

Transcription-coupled repair of DNA lesions takes place across all domains of life. A transcription-elongation factor, ELOF1, highly conserved in eukaryotes, has now been shown to play a key role in this process. Importantly, these findings also include evidence of a second transcription-coupled repair pathway in mammalian cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The role of ELOF1 in TC-NER.

References

  1. Lans, H., Hoeijmakers, J. H. J., Vermeulen, W. & Marteijn, J. A. Nat. Rev. Mol. Cell Biol. 20, 766–784 (2019).

    Article  CAS  Google Scholar 

  2. Geijer, M.E. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00692-z (2021).

  3. van der Weegen, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00688-9 (2021).

  4. Nakazawa, Y. et al. Cell 180, 1228–1244.e24 (2020).

    Article  CAS  Google Scholar 

  5. Tufegdžić Vidaković, A. et al. Cell 80, 1228–1244 (2020).

    Google Scholar 

  6. Olivieri, M. et al. Cell 182, 481–496.e21 (2020).

    Article  CAS  Google Scholar 

  7. Li, S. & Smerdon, M. J. EMBO J. 21, 5921–5929 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Wellcome Trust/Cancer Research UK Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge, UK

    Christopher J. Carnie & Stephen P. Jackson

Authors
  1. Christopher J. Carnie
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen P. Jackson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephen P. Jackson.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Carnie, C.J., Jackson, S.P. The ELOF(1)ant in the room of TCR. Nat Cell Biol 23, 584–586 (2021). https://doi.org/10.1038/s41556-021-00698-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-021-00698-7

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing