Proteins undergoing liquid–liquid phase separation are being discovered at an increasing rate. Since at the high concentrations present in the cell most proteins would be expected to form a liquid condensed state, this state should be considered to be a fundamental state of proteins along with the native state and the amyloid state. Here we discuss the generic nature of the liquid-like and solid-like condensed states, and describe a wide variety of biological functions conferred by these condensed states.
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Fuxreiter, M., Vendruscolo, M. Generic nature of the condensed states of proteins. Nat Cell Biol 23, 587–594 (2021). https://doi.org/10.1038/s41556-021-00697-8