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Tracking skin and immune cell interactions

The distribution of skin immune cells, namely Langerhans cells (LCs) and dendritic epidermal T cells (DETCs), is well-documented, but the mechanisms underlying their pattern maintenance remained obscure. A study now finds that LCs maintain their distribution patterns depending upon Rac1 and that the density of LCs and DETCs is regulated by the density of epithelial cells.

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Fig. 1: Organisation of immune cells in skin epidermis.


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Correspondence to Mayumi Ito.

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Lim, C.H., Ito, M. Tracking skin and immune cell interactions. Nat Cell Biol 23, 439–440 (2021).

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