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GENOME STABILITY

MSL pushes genomic instability over the edge

Nature Cell Biology volume 23, pages 295–296 (2021)Cite this article

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Chromosomal instability (CIN) is a hallmark of malignant evolution that underpins cancer progression and therapeutic evasion. There are few established experimental systems to study CIN and ultimately develop potential therapeutic options. A new study now identifies the MSL chromatin complex as a potential vulnerability against CIN in cancer cells.

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Fig. 1: Role of the MSL complex in tumour cell maintenance.

References

  1. McDonald 3rd, E. R. et al. Cell 170, 577–592.e10 (2017).

    Article  CAS  Google Scholar 

  2. Tsherniak, A. et al. Cell 170, 564–576.e16 (2017).

    Article  CAS  Google Scholar 

  3. Josep, M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00657-2 (2021).

  4. Negrini, S., Gorgoulis, V. G. & Halazonetis, T. D. Nat. Rev. Mol. Cell Biol. 11, 220–228 (2010).

    Article  CAS  Google Scholar 

  5. Sheikh, B. N. & Akhtar, A. Nat. Rev. Genet. 20, 7–23 (2019).

    Article  CAS  Google Scholar 

  6. Scaffidi, P. & Misteli, T. Nat. Cell Biol. 13, 1051–1061 (2011).

    Article  CAS  Google Scholar 

  7. Ben-David, U. & Amon, A. Nat. Rev. Genet. 21, 44–62 (2020).

    Article  CAS  Google Scholar 

  8. Shogren-Knaak, M. et al. Science 311, 844–847 (2006).

    Article  CAS  Google Scholar 

  9. Groth, A., Rocha, W., Verreault, A. & Almouzni, G. Cell 128, 721–733 (2007).

    Article  CAS  Google Scholar 

  10. Clemente-Ruiz, M. et al. Dev. Cell 36, 290–302 (2016).

    Article  CAS  Google Scholar 

  11. Baell, J. B. et al. Nature 560, 253–257 (2018).

    Article  CAS  Google Scholar 

  12. MacPherson, L. et al. Nature 577, 266–270 (2020).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

    Ali Motazedian & Mark A. Dawson

  2. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia

    Ali Motazedian & Mark A. Dawson

  3. The University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia

    Mark A. Dawson

Authors
  1. Ali Motazedian
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  2. Mark A. Dawson
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Correspondence to Mark A. Dawson.

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Competing interests

M.A.D. has been a member of advisory boards for GlaxoSmithKline, CTX CRC, Storm Therapeutics, Celgene and Cambridge Epigenetix. The M.A.D. laboratory received research funding from CTx CRC.

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Motazedian, A., Dawson, M.A. MSL pushes genomic instability over the edge. Nat Cell Biol 23, 295–296 (2021). https://doi.org/10.1038/s41556-021-00666-1

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