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IMMUNOLOGY

STING condensates on ER limit IFN response

Nature Cell Biology volume 23, pages 299–300 (2021)Cite this article

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STING is a key player in the IFN response to cytosolic DNA, and its multimerization is commonly associated with activation of the pathway. A new study now shows that STING forms ‘puzzle’-like condensates to limit the IFN response and constrain antiviral immune activation.

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Fig. 1: A proposed model of STING activation (clockwise) and inhibition (counterclockwise).

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Authors and Affiliations

  1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA, USA

    Liudmila Andreeva & Hao Wu

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  1. Liudmila Andreeva
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  2. Hao Wu
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Correspondence to Hao Wu.

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Competing interests

H.W. is a co-founder of Ventus Therapeutics. L.A. declares no competing interests.

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Andreeva, L., Wu, H. STING condensates on ER limit IFN response. Nat Cell Biol 23, 299–300 (2021). https://doi.org/10.1038/s41556-021-00662-5

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