Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


STING condensates on ER limit IFN response

STING is a key player in the IFN response to cytosolic DNA, and its multimerization is commonly associated with activation of the pathway. A new study now shows that STING forms ‘puzzle’-like condensates to limit the IFN response and constrain antiviral immune activation.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: A proposed model of STING activation (clockwise) and inhibition (counterclockwise).


  1. 1.

    Shi, M., Zhang, P., Vora, S. M. & Wu, H. Curr. Opin. Cell Biol. 63, 194–203 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Ferrao, R., Li, J., Bergamin, E. & Wu, H. Sci. Signal. 5, re3 (2012).

    CAS  Article  Google Scholar 

  3. 3.

    Zhang, L. et al. Science 350, 404–409 (2015).

    CAS  Article  Google Scholar 

  4. 4.

    Jiang, X. et al. Immunity 36, 959–973 (2012).

    CAS  Article  Google Scholar 

  5. 5.

    Andreeva, L. et al. Nature 549, 394–398 (2017).

    CAS  Article  Google Scholar 

  6. 6.

    Yu, X. et al. Nat. Cell Biol. (2021).

  7. 7.

    Barber, G. N. Nat. Rev. Immunol. 15, 760–770 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Dobbs, N. et al. Cell Host Microbe 18, 157–168 (2015).

    CAS  Article  Google Scholar 

  9. 9.

    Haag, S. M. et al. Nature 559, 269–273 (2018).

    CAS  Article  Google Scholar 

  10. 10.

    Shang, G., Zhang, C., Chen, Z. J., Bai, X. C. & Zhang, X. Nature 567, 389–393 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Zhang, C. et al. Nature 567, 394–398 (2019).

    CAS  Article  Google Scholar 

  12. 12.

    Du, M. & Chen, Z. J. Science 361, 704–709 (2018).

    CAS  Article  Google Scholar 

  13. 13.

    Saitoh, T. et al. Proc. Natl. Acad. Sci. USA 106, 20842–20846 (2009).

    CAS  Article  Google Scholar 

  14. 14.

    Samir, P. et al. Nature 573, 590–594 (2019).

    CAS  Article  Google Scholar 

  15. 15.

    Magupalli, V. G. et al. Science 369, eaas8995 (2020).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Hao Wu.

Ethics declarations

Competing interests

H.W. is a co-founder of Ventus Therapeutics. L.A. declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Andreeva, L., Wu, H. STING condensates on ER limit IFN response. Nat Cell Biol 23, 299–300 (2021).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing