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IMMUNOLOGY

STING condensates on ER limit IFN response

STING is a key player in the IFN response to cytosolic DNA, and its multimerization is commonly associated with activation of the pathway. A new study now shows that STING forms ‘puzzle’-like condensates to limit the IFN response and constrain antiviral immune activation.

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Fig. 1: A proposed model of STING activation (clockwise) and inhibition (counterclockwise).

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Correspondence to Hao Wu.

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H.W. is a co-founder of Ventus Therapeutics. L.A. declares no competing interests.

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Andreeva, L., Wu, H. STING condensates on ER limit IFN response. Nat Cell Biol 23, 299–300 (2021). https://doi.org/10.1038/s41556-021-00662-5

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