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Condensing and constraining WNT by TGF-β

TGF-β can antagonise or cooperate with WNT signalling, yet it is still unclear what mechanisms integrate the outcomes of these conserved pathways. A new study now reports that the formation of biomolecular condensates, dependent on the DACT1 protein, provides the spatial segregation needed for TGF-β to constrain WNT signalling.

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Fig. 1: Activation of canonical WNT and TGF-β receptors lead to distinct, but integrated downstream signalling pathways.

References

  1. 1.

    David, C. J. & Massagué, J. Nat. Rev. Mol. Cell Biol. 19, 419–435 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Esposito, M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00641-w (2021).

  3. 3.

    Nusse, R. & Clevers, H. Cell 169, 985–999 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Esposito, M., Guise, T. & Kang, Y. Cold Spring Harb. Perspect. Med. 8, a031252 (2018).

    Article  Google Scholar 

  5. 5.

    Gloy, J., Hikasa, H. & Sokol, S. Y. Nat. Cell Biol. 4, 351–357 (2002).

    CAS  Article  Google Scholar 

  6. 6.

    Cheyette, B. N. R. et al. Dev. Cell 2, 449–461 (2002).

    CAS  Article  Google Scholar 

  7. 7.

    Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K. Nat. Rev. Mol. Cell Biol. 18, 285–298 (2017).

    CAS  Article  Google Scholar 

  8. 8.

    Shin, Y. & Brangwynne, C. P. Science 357, eaaf4382 (2017).

    Article  Google Scholar 

  9. 9.

    Brangwynne, C. P. et al. Science 324, 1729–1732 (2009).

    CAS  Article  Google Scholar 

  10. 10.

    Klosin, A. et al. Science 367, 464–468 (2020).

    CAS  Article  Google Scholar 

  11. 11.

    Lyon, A. S., Peeples, W. B. & Rosen, M. K. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-020-00303-z (2020).

  12. 12.

    Schaefer, K. N. & Peifer, M. Dev. Cell 48, 429–444 (2019).

    CAS  Article  Google Scholar 

  13. 13.

    Vinayagam, A. et al. Sci. Signal. 4, rs8 (2011).

    Article  Google Scholar 

  14. 14.

    Dominguez, I., Sonenshein, G. E. & Seldin, D. C. Cell. Mol. Life Sci. 66, 1850–1857 (2009).

    CAS  Article  Google Scholar 

  15. 15.

    Mariz, K., Ingolf, J. B., Daniel, H., Teresa, N. J. & Erich-Franz, S. Clin. Exp. Metastasis 32, 857–866 (2015).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Don X. Nguyen.

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D.X.N. has received research support from AstraZeneca, Inc.

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Patel, K.D., Nguyen, D.X. Condensing and constraining WNT by TGF-β. Nat Cell Biol 23, 213–214 (2021). https://doi.org/10.1038/s41556-021-00649-2

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