In response to cold stress, mammals release norepinephrine from the sympathetic nervous system to elevate thermogenesis in brown adipose tissue (BAT) in order to maintain body temperature. This study reveals that the protein AIDA connects sympathetic input, reactive oxygen species, and uncoupling protein 1-mediated adaptive thermogenesis in BAT.
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The authors declare no competing interests.
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Mills, E.L., Xiao, H. & Chouchani, E.T. AIDA and UCP1 snuggle up to prevent hypothermia. Nat Cell Biol 23, 216–218 (2021). https://doi.org/10.1038/s41556-021-00648-3