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A circuitous route to GBM stem cell signalling

Circular RNAs regulate a variety of biological processes. Now an unexpected pathway is revealed in which a translated circular RNA derived from E-cadherin pre-mRNA activates EGFR signalling in glioblastoma cancer stem cells and acts as a ligand for the EGFR mutant EGFRVIII, a common oncogenic variant.

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Fig. 1: E-cadherin pre-mRNA is processed differently in neural stem cells (NSCs) and glioblastoma stem cells (GSCs).


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Correspondence to Justin D. Lathia.

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Mitchell, K., Lathia, J.D. A circuitous route to GBM stem cell signalling. Nat Cell Biol 23, 211–212 (2021).

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