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A circuitous route to GBM stem cell signalling

Nature Cell Biology volume 23, pages 211–212 (2021)Cite this article

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Circular RNAs regulate a variety of biological processes. Now an unexpected pathway is revealed in which a translated circular RNA derived from E-cadherin pre-mRNA activates EGFR signalling in glioblastoma cancer stem cells and acts as a ligand for the EGFR mutant EGFRVIII, a common oncogenic variant.

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Fig. 1: E-cadherin pre-mRNA is processed differently in neural stem cells (NSCs) and glioblastoma stem cells (GSCs).

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Authors and Affiliations

  1. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Kelly Mitchell & Justin D. Lathia

  2. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA

    Kelly Mitchell & Justin D. Lathia

  3. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA

    Justin D. Lathia

  4. Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Ohio, USA

    Justin D. Lathia

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  1. Kelly Mitchell
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  2. Justin D. Lathia
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Correspondence to Justin D. Lathia.

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Mitchell, K., Lathia, J.D. A circuitous route to GBM stem cell signalling. Nat Cell Biol 23, 211–212 (2021). https://doi.org/10.1038/s41556-021-00643-8

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