Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

METABOLISM

The return of quiescence metabolites

The transition of endothelial cells between quiescence and proliferation is essential for regulating the extent of the vasculature that supplies oxygen and nutrients to tissues. A study now shows that the FOXO1 transcription factor regulates endothelial cell proliferation by controlling levels of the metabolite 2-hydroxyglutarate.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Schematic of proposed regulatory pathway.

References

  1. 1.

    Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Science 324, 1029–1033 (2009).

    Article  Google Scholar 

  2. 2.

    Wise, D. R. et al. Proc. Natl. Acad. Sci. USA 105, 18782–18787 (2008).

    CAS  Article  Google Scholar 

  3. 3.

    Gao, P. et al. Nature 458, 762–765 (2009).

    CAS  Article  Google Scholar 

  4. 4.

    Bensaad, K. et al. Cell 126, 107–120 (2006).

    CAS  Article  Google Scholar 

  5. 5.

    Potente, M. et al. J. Clin. Invest. 115, 2382–2392 (2005).

    CAS  Article  Google Scholar 

  6. 6.

    Andrade, J. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00637-6 (2021).

  7. 7.

    Tzivion, G., Dobson, M. & Ramakrishnan, G. Biochim. Biophys. Acta 1813, 1938–1945 (2011).

    CAS  Article  Google Scholar 

  8. 8.

    Wilhelm, K. et al. Nature 529, 216–220 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Gross, S. et al. J. Exp. Med. 207, 339–344 (2010).

    CAS  Article  Google Scholar 

  10. 10.

    Chowdhury, R. et al. EMBO Rep. 12, 463–469 (2011).

    CAS  Article  Google Scholar 

  11. 11.

    Xu, W. et al. Cancer Cell 19, 17–30 (2011).

    CAS  Article  Google Scholar 

  12. 12.

    Tarhonskaya, H. et al. Nat. Commun. 5, 3423 (2014).

    Article  Google Scholar 

  13. 13.

    Chaturvedi, A. et al. Leukemia 30, 1708–1715 (2016).

    CAS  Article  Google Scholar 

  14. 14.

    Patel, M. S. Biochem. J. 144, 91–97 (1974).

    CAS  Article  Google Scholar 

  15. 15.

    Valcourt, J. R. et al. Cell Cycle 11, 1680–1696 (2012).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

The author would like to acknowledge support from NCI R01 CA221296, R01 AR070245, the Melanoma Research Alliance, the Cancer Research Institute, the Broad Stem Cell Center, and the Jonsson Comprehensive Cancer Center.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Hilary A. Coller.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Coller, H.A. The return of quiescence metabolites. Nat Cell Biol 23, 303–304 (2021). https://doi.org/10.1038/s41556-021-00640-x

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing