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The return of quiescence metabolites

The transition of endothelial cells between quiescence and proliferation is essential for regulating the extent of the vasculature that supplies oxygen and nutrients to tissues. A study now shows that the FOXO1 transcription factor regulates endothelial cell proliferation by controlling levels of the metabolite 2-hydroxyglutarate.

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Fig. 1: Schematic of proposed regulatory pathway.


  1. 1.

    Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Science 324, 1029–1033 (2009).

    Article  Google Scholar 

  2. 2.

    Wise, D. R. et al. Proc. Natl. Acad. Sci. USA 105, 18782–18787 (2008).

    CAS  Article  Google Scholar 

  3. 3.

    Gao, P. et al. Nature 458, 762–765 (2009).

    CAS  Article  Google Scholar 

  4. 4.

    Bensaad, K. et al. Cell 126, 107–120 (2006).

    CAS  Article  Google Scholar 

  5. 5.

    Potente, M. et al. J. Clin. Invest. 115, 2382–2392 (2005).

    CAS  Article  Google Scholar 

  6. 6.

    Andrade, J. et al. Nat. Cell Biol. (2021).

  7. 7.

    Tzivion, G., Dobson, M. & Ramakrishnan, G. Biochim. Biophys. Acta 1813, 1938–1945 (2011).

    CAS  Article  Google Scholar 

  8. 8.

    Wilhelm, K. et al. Nature 529, 216–220 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Gross, S. et al. J. Exp. Med. 207, 339–344 (2010).

    CAS  Article  Google Scholar 

  10. 10.

    Chowdhury, R. et al. EMBO Rep. 12, 463–469 (2011).

    CAS  Article  Google Scholar 

  11. 11.

    Xu, W. et al. Cancer Cell 19, 17–30 (2011).

    CAS  Article  Google Scholar 

  12. 12.

    Tarhonskaya, H. et al. Nat. Commun. 5, 3423 (2014).

    Article  Google Scholar 

  13. 13.

    Chaturvedi, A. et al. Leukemia 30, 1708–1715 (2016).

    CAS  Article  Google Scholar 

  14. 14.

    Patel, M. S. Biochem. J. 144, 91–97 (1974).

    CAS  Article  Google Scholar 

  15. 15.

    Valcourt, J. R. et al. Cell Cycle 11, 1680–1696 (2012).

    CAS  Article  Google Scholar 

Download references


The author would like to acknowledge support from NCI R01 CA221296, R01 AR070245, the Melanoma Research Alliance, the Cancer Research Institute, the Broad Stem Cell Center, and the Jonsson Comprehensive Cancer Center.

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Correspondence to Hilary A. Coller.

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Coller, H.A. The return of quiescence metabolites. Nat Cell Biol 23, 303–304 (2021).

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